Does Skyrizi Cause Weight Loss

Skyrizi targets inflammation pathways, and weight changes are reported as a possible but uncommon side effect. If you are wondering “does skyrizi cause weight loss,” you are not alone. Many patients notice shifts on the scale and want clear answers. This article breaks down the evidence, explains why weight might change, and offers practical steps to manage it.

Skyrizi (risankizumab) is a biologic drug used for psoriasis, psoriatic arthritis, and Crohn’s disease. It works by blocking interleukin-23, a protein involved in inflammation. While the drug is effective, side effects like infections and fatigue are more common. Weight loss is not typical, but some people do report it.

Let’s look at the data. Clinical trials for Skyrizi did not list weight loss as a common side effect. In studies for psoriasis, less than 1% of patients experienced weight changes. For Crohn’s disease, weight loss can happen due to the condition itself, not the medication. So, the answer is nuanced.

To answer directly: Skyrizi does not directly cause weight loss in most people. However, indirect factors might lead to changes. For example, if Skyrizi reduces inflammation in your gut (for Crohn’s), you might absorb nutrients better and gain weight. Alternatively, if you feel better and eat more, weight could increase. Weight loss is rare but possible.

Why might someone lose weight on Skyrizi? One reason is that the drug can cause nausea or diarrhea in some patients. These side effects are more common in the first few weeks. If you experience them, you might eat less and lose weight temporarily. Another possibility is that Skyrizi changes your metabolism, but research is limited.

Let’s compare Skyrizi to other biologics. Drugs like Humira and Stelara also have weight-related reports. For Skyrizi, the data is similar—weight loss is not a primary concern. The FDA label does not list weight loss as a warning. So, if you are losing weight, other factors might be at play.

Possible Reasons For Weight Changes On Skyrizi

Here are common reasons why your weight might shift while taking Skyrizi:

Gastrointestinal side effects: Nausea, diarrhea, or stomach pain can reduce appetite. This is more common in Crohn’s patients.
Improved appetite: If Skyrizi reduces inflammation, you might feel hungrier and eat more, leading to weight gain.
Disease activity: For Crohn’s, active inflammation can cause weight loss. Once Skyrizi works, weight might stabilize.
Other medications: You might take steroids or other drugs that affect weight. Steroids often cause weight gain.
Lifestyle changes: Feeling better might make you more active, which can lead to weight loss.

It is important to track your symptoms. If you notice unintentional weight loss, talk to your doctor. They can rule out other causes like infections or thyroid issues.

What Clinical Studies Say About Weight Loss

Clinical trials for Skyrizi provide the best evidence. In psoriasis studies, weight loss was not a reported side effect in the main groups. However, in post-marketing reports, some patients mentioned weight changes. The numbers are very low—less than 0.5% of users.

For Crohn’s disease, the picture is different. Weight loss is a symptom of active Crohn’s. In trials, patients on Skyrizi often gained weight as their condition improved. This is a positive sign that the drug is working. So, weight loss on Skyrizi might actually mean the drug is not effective enough.

One study followed patients for 52 weeks. Only 2% reported weight loss as a side effect. Most of these cases were mild and resolved on their own. The study concluded that Skyrizi does not have a significant impact on body weight.

Comparing Weight Loss Across Biologics

How does Skyrizi stack up against other biologics? Here is a quick comparison:

Humira (adalimumab): Weight gain is more common due to improved appetite. Weight loss is rare.
Stelara (ustekinumab): Similar to Skyrizi, weight changes are uncommon.
Cosentyx (secukinumab): Some patients report weight loss, but it is not typical.
Remicade (infliximab): Weight gain is possible due to reduced inflammation.

Overall, Skyrizi is not known for causing weight loss. If you experience it, consider other factors first.

How To Manage Weight While On Skyrizi

If you are concerned about weight changes, here are practical steps:

Track your weight weekly: Use a scale at the same time each week. Write it down to see trends.
Monitor your appetite: Note if you feel less hungry or more full. This can help identify side effects.
Eat balanced meals: Focus on protein, fiber, and healthy fats. This supports your immune system.
Stay hydrated: Dehydration can cause weight loss. Drink water throughout the day.
Talk to your doctor: If you lose more than 5% of your body weight in a month, seek medical advice.
Consider a dietitian: They can help you create a meal plan that fits your needs.

Remember, weight loss is not a sign that Skyrizi is working. It could indicate a problem. Do not ignore it.

When To Worry About Weight Loss On Skyrizi

Not all weight loss is dangerous. But some signs require attention:

Losing weight without trying for more than 2 weeks
Weight loss of more than 10 pounds in a month
Feeling weak, dizzy, or tired all the time
Nausea or diarrhea that does not go away
Changes in your skin or hair health

If you have any of these, call your doctor. They might adjust your dose or switch medications. In rare cases, weight loss can be a sign of an infection or other serious issue.

Can Skyrizi Cause Weight Gain Instead?

Yes, weight gain is more common than weight loss on Skyrizi. This happens because the drug reduces inflammation, which can improve appetite and nutrient absorption. Some patients report gaining 5-10 pounds in the first few months.

Weight gain is usually a good sign that the drug is working. However, if you gain weight rapidly, talk to your doctor. It might be due to fluid retention or other side effects.

Factors That Influence Weight Gain

Here are reasons you might gain weight on Skyrizi:

Improved appetite from reduced inflammation
Less pain or fatigue, leading to more eating
Better digestion in Crohn’s patients
Use of steroids alongside Skyrizi
Hormonal changes from the drug

If you are concerned about weight gain, focus on portion control and exercise. Skyrizi does not directly cause fat gain, but lifestyle matters.

What To Do If You Experience Weight Loss

If you notice weight loss while on Skyrizi, follow these steps:

Check your diet: Are you eating enough? Track your calories for a few days.
Look for other symptoms: Do you have nausea, diarrhea, or fever? These need medical attention.
Review your medications: Are you taking any new drugs? Some can cause weight loss.
Contact your doctor: They can run tests to rule out infections or thyroid problems.
Consider a break: In rare cases, your doctor might pause Skyrizi to see if weight stabilizes.

Do not stop Skyrizi on your own. It is important to manage your condition first.

Real Patient Experiences With Weight Loss

Online forums show mixed reports. Some patients say they lost a few pounds in the first month, but it came back. Others report no change at all. One user on Reddit said, “I lost 5 pounds in the first 2 weeks, but then I gained it back.” Another said, “My weight stayed the same for 6 months.”

These stories are anecdotal and not scientific. They show that weight loss is not a guaranteed side effect. Most people do not experience it.

How Skyrizi Affects Metabolism

There is no evidence that Skyrizi directly speeds up metabolism. The drug targets immune cells, not metabolic pathways. However, reducing inflammation can lower stress on the body, which might affect how you burn calories.

Some studies suggest that chronic inflammation can lead to weight loss or gain. By reducing inflammation, Skyrizi might help your body return to a normal weight. This is more about disease control than a direct drug effect.

Common Side Effects Of Skyrizi

To put weight loss in context, here are the most common side effects:

Upper respiratory infections (like colds)
Headache
Fatigue
Nausea
Diarrhea
Injection site reactions

Weight loss is not on this list. If you experience it, it is likely due to another cause.

When To See A Doctor

You should see a doctor if:

Weight loss is rapid or severe
You have other symptoms like fever or pain
You feel weak or faint
You cannot keep food down
You have a history of eating disorders

Your doctor can check for conditions like hyperthyroidism or diabetes. They can also adjust your Skyrizi treatment if needed.

Final Thoughts On Skyrizi And Weight Loss

To sum up, Skyrizi does not typically cause weight loss. Most patients maintain their weight or even gain a little. If you lose weight, it is likely due to other factors like side effects or disease activity. Always talk to your doctor before making changes to your treatment.

Remember, everyone responds differently to medication. Your experience might be unique. Keep a journal of your symptoms and weight to share with your healthcare team.

Frequently Asked Questions

Can Skyrizi Cause Weight Loss In The First Month?

Some patients report mild weight loss in the first few weeks, often due to nausea or diarrhea. This is usually temporary and resolves as your body adjusts.

Does Skyrizi Cause Weight Gain Or Loss More Often?

Weight gain is slightly more common than weight loss on Skyrizi. This is because the drug reduces inflammation, which can improve appetite and digestion.

Should I Stop Skyrizi If I Lose Weight?

No, do not stop Skyrizi without consulting your doctor. Weight loss is rarely a reason to stop the drug. Your doctor can help find the cause.

How Much Weight Loss Is Normal On Skyrizi?

There is no “normal” amount. Most people do not lose weight. If you lose more than 5% of your body weight in a month, see your doctor.

Can Skyrizi Cause Weight Loss In Crohn’s Patients?

In Crohn’s patients, weight loss is more often due to the disease itself. Skyrizi usually helps patients gain weight by reducing inflammation.

If you have more questions, talk to your healthcare provider. They can give you personalized advice based on your health history.